Is CVE-2025-10999 exploited in the wild?

No. Junglewise Threat Intelligence has no report of CVE-2025-10999 being exploited in the wild.

How severe is CVE-2025-10999?

Medium severity, with a CVSS score of 5.5, published 1 July 2026.

Which products and versions are affected?

openbabel (PyPI) < 3.2.0, ECOSYSTEM:introduced=0,fixed=3.2.0.

Is there a fix for CVE-2025-10999?

Yes. openbabel (PyPI): upgrade to 3.2.0 or later. Junglewise finds every place you run it, drafts the upgrade and applies it once you approve.

How is CVE-2025-10999 attacked?

It is attacked with local access, in a software library.

Am I affected by CVE-2025-10999?

Check whether you run openbabel (PyPI) at an affected version. Junglewise does that check for you around the clock: connect your code, cloud and domains, and it matches new vulnerabilities like this one against what you actually run and tells you when one reaches you.

CVE-2025-10999: Open Babel NULL pointer dereference in CacaoFormat::SetHilderbrandt

Q: Which products and versions are affected?

openbabel (PyPI) < 3.2.0, ECOSYSTEM:introduced=0,fixed=3.2.0.

Q: Is there a fix for CVE-2025-10999?

Yes. openbabel (PyPI): upgrade to 3.2.0 or later. Junglewise finds every place you run it, drafts the upgrade and applies it once you approve.

Q: How is CVE-2025-10999 attacked?

It is attacked with local access, in a software library.

Q: Am I affected by CVE-2025-10999?

Check whether you run openbabel (PyPI) at an affected version. Junglewise does that check for you around the clock: connect your code, cloud and domains, and it matches new vulnerabilities like this one against what you actually run and tells you when one reaches you.

CVE-2025-10999 · Severity: medium · CVSS 5.5 · Published 2026-07-01

Open Babel is a widely used software library for processing chemical data and file formats. A vulnerability in its CACAO file parser allows an attacker to crash applications using the library by providing a specially crafted chemistry file. This could lead to a denial-of-service, affecting researchers and automated chemical analysis services that process untrusted data.

Technologies: openbabel (PyPI). Vendors: PyPI.

Quick answers

Is CVE-2025-10999 exploited in the wild?: No. Junglewise Threat Intelligence has no report of CVE-2025-10999 being exploited in the wild.
How severe is CVE-2025-10999?: Medium severity, with a CVSS score of 5.5, published 1 July 2026.
Which products and versions are affected?: openbabel (PyPI) < 3.2.0, ECOSYSTEM:introduced=0,fixed=3.2.0.
Is there a fix for CVE-2025-10999?: Yes. openbabel (PyPI): upgrade to 3.2.0 or later. Junglewise finds every place you run it, drafts the upgrade and applies it once you approve.
How is CVE-2025-10999 attacked?: It is attacked with local access, in a software library.
Am I affected by CVE-2025-10999?: Check whether you run openbabel (PyPI) at an affected version. Junglewise does that check for you around the clock: connect your code, cloud and domains, and it matches new vulnerabilities like this one against what you actually run and tells you when one reaches you.

How to fix

openbabel (PyPI): upgrade to 3.2.0 or later
```
pip install "openbabel>=3.2.0"
```

Technical details

A NULL pointer dereference exists in the CacaoFormat::SetHilderbrandt function within src/formats/cacaoformat.cpp. The vulnerability is triggered when the parser applies the Hilderbrandt transformation to a malformed CACAO input file that contains invalid internal coordinate references. Specifically, the code assumes all OBAtom pointers in the internal coordinate list are valid; a crafted file can provide null or corrupted pointers, leading to a crash (SEGV) when OBAtom::GetIdx() is called. This affects the obabel CLI tool, the OBConversion API, and all language bindings. The issue is fixed in version 3.2.0.

Affected products

Open Babel Open Babel <= 3.1.1

Identifiers

CVE-2025-10999
GHSA-55j6-rjhx-hwfh
PYSEC-2026-2772

Timeline

2025-09-14: disclosed: Initial bug report via OSS-Fuzz/GitHub issues
2026-05-26: patched: Version 3.2.0 released
2026-07-01: advisory: GitHub Advisory published

References

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