Junglewise Threat Intelligence

CVE-2022-46280: Open Babel uninitialized pointer dereference in PQS parser

CVE-2022-46280 · Severity: high · CVSS 7.8 · Published 2026-07-01

Technologies: Open Babel, openbabel (PyPI). Vendors: PyPI.

Executive brief

Open Babel, a widely used library for converting chemical and molecular data formats, contains a memory safety flaw in its PQS file parser. An attacker could provide a specially crafted PQS file that, when opened by a user or processed by a service using this library, could lead to a program crash or potentially allow the execution of unauthorized code. This affects researchers and organizations using Open Babel for chemistry data analysis or web-based molecule viewers.

Technical details

A memory-safety vulnerability exists in Open Babel's PQS parser due to an uninitialized pointer dereference in the `pFormat` handling of the PQS reader. The flaw occurs within `PQSFormat::ReadMolecule` in `formats/PQSformat.cpp` when processing malformed input that causes the parser to access a format pointer before it has been properly initialized. An attacker can exploit this by providing a crafted PQS file to be processed via the `obabel` CLI tool, the `OBConversion` API, or any of the library's language bindings (Python, Ruby, Java, etc.). Successful exploitation could lead to arbitrary code execution or a crash. The issue is addressed in version 3.2.0 by ensuring the pointer is initialized to `nullptr` and verified before use.

Affected products

  • Open Babel Open Babel Up to and including 3.1.1

Timeline

  • 2023-07-21: disclosed: Initial Talos report published
  • 2026-05-26: patched: Version 3.2.0 released
  • 2026-07-01: advisory: GitHub Advisory published

References

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